Publications | The Wei Lab

Prior to Caltech:

20. Electronic Resonant Stimulated Raman Scattering Micro-Spectroscopy

H. Xiong†, L. Shi†, L. Wei, Y. Shen, R. Long, Z. Zhao and W. Min, Nat. Photonics, 13, 412 (2019). †Equal Contributions

19. Electronic pre-resonance stimulated Raman scattering microscopy

L. Wei and W. Min, J. Phys. Chem. Lett. 9, 4294 (2018). Cover.

18. Operando, three dimensional, and simultaneous visualization of ion depletion and lithium growth by stimulated Raman scattering microscopy

Q. Cheng†, L. Wei†, Z. Liu, N. Ni, Z. Sang, B. Zhu, W. Xu, L.-Q.Chen, W. Min and Y. Yang, Nat. Commun., 9, 2942 (2018). †Equal contribution.

17. Supermultiplexed optical imaging and barcoding with engineered polyynes

F. Hu, C. Zeng, R. Long, Y. Miao, L. Wei, Q. Xu and W. Min, Nat. Methods, 15, 194(2018).

16. Super-multiplex vibrational imaging

L. Wei, Z. Chen, L. Shi, R. Long, A. V. Anzalone, L. Zhang, F. Hu, R. Yuste, V. W. Cornish and W. Min, Nature, 544, 465 (2017).

“A larger palette for biological imaging” featured by Nature News & Views.

“New dyes enable super-multicolor imaging”, featured by Chem & Engn News.

“Good vibrations for super-multiplexed imaging” featured by Nature Methods.

“New microscopy method breaks color barrier of optical imaging” featured by Phys.org.

“Expanding Bioimaging's Palette” featured by Optics & Photonics News.

15. Live-cell bioorthogonal chemical imaging: stimulated Raman scattering microscopy of vibrational probes

L. Wei, F. Hu, Z. Chen, Y. Shen, L. Zhang and W. Min, Acc. Chem. Res.,49,1494 (2016).

14. Bioorthogonal chemical imaging of metabolic activities in live mammalian hippocampal tissues with stimulated Raman scattering

F. Hu, M. Lamprecht, L. Wei, B. Morrison and W. Min, Sci. Rep.,6, 39660 (2016).

13. Imaging complex protein metabolism in live organisms by stimulated Raman scattering microscopy with isotope labeling

L. Wei, Y. Shen, F. Xu, F. Hu, J. K. Harrington, K. L. Targoff and W. Min. ACS Chem. Bio.10, 901 (2015). Cover.

12. Vibrational imaging of glucose uptake activity in live cells and tissues by stimulated Raman scattering

F. Hu, Z. Chen, L. Zhang, Y. Shen, L. Wei and W. Min. Angew. Chem. Int. Ed. 54, 9821 (2015).

11. Live-cell imaging of alkyne-tagged small biomolecules by stimulated Raman Scattering

L. Wei, F. Hu, Y. Shen, Z. Chen, Y. Yu, C. -C. Lin, M. C. Wang and W. Min. Nat. Methods, 11, 410 (2014).

10. Multicolor live-cell chemical imaging by isotopically edited alkyne vibrational palette

Z. Chen, D. Paley, L. Wei, A. Weisman, R. Friesner, C. Nuckolls and W. Min. J. Am. Chem. Soc. 136, 8027 (2014).

9. Live-cell quantitative imaging of proteome degradation by stimulated Raman scattering

Y. Shen, F Xu, L. Wei, F. Hu and W. Min, Angew. Chem. Int. Ed.53, 5596 (2014).

8. Vibrational imaging of choline metabolites in live cells by stimulated Raman scattering coupled with isotope-based metabolic labeling

F. Hu, L. Wei, C. Zheng, Y. Shen and W. Min, Analyst, 139, 2312 (2014). Cover.

7. Vibrational imaging of newly synthesized proteins in live cells by stimulated Raman scattering microscopy

L. Wei, Y. Yu, Y. Shen, M. Wang and W. Min, Proc. Natl. Acad. Sci. USA,110, 11226 (2013).

6. Frustrated FRET for high-contrast high-resolution two-photon imaging

F. Xu, L. Wei, Z. Chen and W. Min. Opt. Express, 12, 14097 (2013).

5. What can stimulated emission do for bio-imaging?

L. Wei and W. Min. Ann. N. Y. Acad. Sci., 1293,1 (2013).

4. Pump-probe optical microscopy for imaging non-fluorescent chromophores

L. Wei and W. Min. Anal. Bioanal. Chem.403, 2197 (2012).

3. Mapping protein-specific micro-environments in live cells by fluorescence lifetime imaging of a hybrid genetic-chemical molecular rotor tag

E. Gatzogiannis, Z. Chen, L. Wei, R. Wombacher, Y. -T. Kao, G. Yefremov, V. C. Cornish and W. Min. Chem. Commun. 48, 8694 (2012).

2. Extending the fundamental imaging-depth limit of multi-photon microscopy by imaging with photo-activatable fluorophores

Z. Chen†, L. Wei†, X. Zhu† and W. Min. Opt. Express 20, 18525 (2012). †Equal contribution

1. Stimulated emission reduced fluorescence microscopy: a concept for extending the fundamental depth limit of two-photon fluorescence imaging

L. Wei, Z. Chen and W. Min. Biomed. Opt. Express 3, 1465 (2012).

35. Bond-selective Fluorescence Imaging with Single-molecule Sensitivity

H. Wang†, D. Lee†, Y. Cao, X. Bi, J. Du, K. Miao & L. Wei*, Nature Photonics (2023) (†Equal Contributions)

34. Computational Design of Molecular Probes for Electronic Preresonance Raman Scattering Microscopy

J. Du†, X. Tao†, T. Begušić, & L. Wei, J. Phys. Chem. B, 127, 22, 4979–4988 (2023) (†Equal Contributions, *Co-corresponding)

33. Toward the Next Frontiers of Vibrational Imaging

H. Wang, D. Lee, & L. Wei*, Chem. & Biomed. Imaging. 1, 1, 3–17 (2023).

32. Bringing Vibrational Imaging to Chemical Biology With Molecular Probes

J. Du, H. Wang & L. Wei*, ACS Chem. Biol. 17, 7, 1621–1637 (2022).

31. Label-free Super-resolution Imaging Enabled by Vibrational Imaging of Swelled Tissue and Analysis

K. Miao, L. Lin, C. Qian & L. Wei*, J. Vis. Exp. (183), e63824, (2022).

30. Alkyne-Tagged Raman Probes for Local Environmental Sensing by Hydrogen–Deuterium Exchange

X. Bi†, K. Miao† & L. Wei*, J. Am. Chem. Soc. 144, 19, 8504–8514 (2022). †Equal Contributions

29. Multicolor Photoactivatable Raman Probes for Subcellular Imaging and Tracking by Cyclopropenone Caging

J. Du & L. Wei*, J. Am. Chem. Soc.144, 2, 777–786 (2022).

28. Super-Resolution Label-free Volumetric Vibrational Imaging

C. Qian†, K. Miao†, L. Lin, X. Chen, J. Du, L. Wei*, Nature Communications, 3648 (2021). †Equal Contributions

“Microscopy method achieves superresolution without labels”,

featured by C&EN.

"C&EN’s Year in Chemistry 2021"

27. High spatial-resolution imaging of label-free in vivo protein aggregates by VISTA

L. Lin, K. Miao, C. Qian, L. Wei*, Analyst, 146, 4135-4145 (2021).

26. Toward Photoswitchable Pre-resonance Stimulated Raman Probes

D. Lee, C. Qian, H. Wang, L. Lei, K. Miao, J. Du, D. M. Shcherbakova, V. V. Verkhusha, L.V. Wang, and L. Wei*, Journal of Chemical Physics, 154, 135102, (2021).

- As a part of the 2021 JCP Emerging Investigators Special Collection

- JCP Editors’ Choice 2021

- Featured article

25. Visualizing Subcellular Enrichment of Glycogen in Live Cancer Cells by Stimulated Raman Scattering

D. Lee, J. Du, R. Yu, Y. Su, J. Heath, and L. Wei*, Analytical Chemistry, 92, 13182, (2020).

24. Raman-guided Subcellular Pharmaco-Metabolomics for Metastatic Melanoma Cells

J. Du†, Y. Su†, C. Qian, D. Yuan, K. Miao, D. Lee, A. Ng, R. Wijker, A. Ribas, R. Levine, J. Heath, and L. Wei, Nature Communications, 11, 4830, (2020). †Equal Contributions

"Cancer’s hidden vulnerabilities"

23. Live-Cell Imaging and Quantification of PolyQ Aggregates by Stimulated Raman Scattering of Selective Deuterium Labeling

K. Miao and L. Wei*, ACS Cent. Sci, 4, 478, (2020).

22. Volumetric Chemical Imaging by Clearing-Enhanced Stimulated Raman Scattering Microscopy

M. Wei†, L. Shi†, Y. Shen, Z. Zhao, A. Guzman, L. J. Kaufman, L. Wei* and Wei Min, Proc. Natl. Acad. Sci. USA, 116, 6608, (2019). (†Equal Contributions Co-corresponding)

21. Stimulated Raman excited fluorescence spectroscopy and imaging

H. Xiong†, L. Shi†, L. Wei, Y. Shen, R. Long, Z. Zhao and W. Min, Nat. Photonics, 13, 412 (2019). †Equal Contributions

Nature_Communications_Fig7-1_rescaled.pn

scaled_Result of FEIR--910mW-150mW-ND3-1-0001-2.png

Prior to Caltech: 20. Electronic Resonant Stimulated Raman Scattering Micro-Spectroscopy

H. Xiong†, L. Shi†, L. Wei, Y. Shen, R. Long, Z. Zhao and W. Min, Nat. Photonics, 13, 412 (2019). †Equal Contributions

L. Wei and W. Min, J. Phys. Chem. Lett. 9, 4294 (2018). Cover.

Q. Cheng†, L. Wei†, Z. Liu, N. Ni, Z. Sang, B. Zhu, W. Xu, L.-Q.Chen, W. Min and Y. Yang, Nat. Commun., 9, 2942 (2018). †Equal contribution.

F. Hu, C. Zeng, R. Long, Y. Miao, L. Wei, Q. Xu and W. Min, Nat. Methods, 15, 194(2018).

L. Wei, Z. Chen, L. Shi, R. Long, A. V. Anzalone, L. Zhang, F. Hu, R. Yuste, V. W. Cornish and W. Min, Nature, 544, 465 (2017).

L. Wei, F. Hu, Z. Chen, Y. Shen, L. Zhang and W. Min, Acc. Chem. Res.,49,1494 (2016).

F. Hu, M. Lamprecht, L. Wei, B. Morrison and W. Min, Sci. Rep.,6, 39660 (2016).

L. Wei, Y. Shen, F. Xu, F. Hu, J. K. Harrington, K. L. Targoff and W. Min. ACS Chem. Bio.10, 901 (2015). Cover.

F. Hu, Z. Chen, L. Zhang, Y. Shen, L. Wei and W. Min. Angew. Chem. Int. Ed. 54, 9821 (2015).

L. Wei, F. Hu, Y. Shen, Z. Chen, Y. Yu, C. -C. Lin, M. C. Wang and W. Min. Nat. Methods, 11, 410 (2014).

Z. Chen, D. Paley, L. Wei, A. Weisman, R. Friesner, C. Nuckolls and W. Min. J. Am. Chem. Soc. 136, 8027 (2014).

Y. Shen, F Xu, L. Wei, F. Hu and W. Min, Angew. Chem. Int. Ed.53, 5596 (2014).

F. Hu, L. Wei, C. Zheng, Y. Shen and W. Min, Analyst, 139, 2312 (2014). Cover.

L. Wei, Y. Yu, Y. Shen, M. Wang and W. Min, Proc. Natl. Acad. Sci. USA,110, 11226 (2013).

F. Xu, L. Wei, Z. Chen and W. Min. Opt. Express, 12, 14097 (2013).

L. Wei and W. Min. Ann. N. Y. Acad. Sci., 1293,1 (2013).

L. Wei and W. Min. Anal. Bioanal. Chem.403, 2197 (2012).

E. Gatzogiannis, Z. Chen, L. Wei, R. Wombacher, Y. -T. Kao, G. Yefremov, V. C. Cornish and W. Min. Chem. Commun. 48, 8694 (2012).

Z. Chen†, L. Wei†, X. Zhu† and W. Min. Opt. Express 20, 18525 (2012). †Equal contribution

L. Wei, Z. Chen and W. Min. Biomed. Opt. Express 3, 1465 (2012).

H. Wang†, D. Lee†, Y. Cao, X. Bi, J. Du, K. Miao & L. Wei*, Nature Photonics (2023) (†Equal Contributions)

J. Du†, X. Tao†, T. Begušić*, & L. Wei*, J. Phys. Chem. B, 127, 22, 4979–4988 (2023) (†Equal Contributions, *Co-corresponding)

H. Wang, D. Lee, & L. Wei*, Chem. & Biomed. Imaging. 1, 1, 3–17 (2023).

J. Du, H. Wang & L. Wei*, ACS Chem. Biol. 17, 7, 1621–1637 (2022).

K. Miao, L. Lin, C. Qian & L. Wei*, J. Vis. Exp. (183), e63824, (2022).

X. Bi†, K. Miao† & L. Wei*, J. Am. Chem. Soc. 144, 19, 8504–8514 (2022). †Equal Contributions

J. Du & L. Wei*, J. Am. Chem. Soc.144, 2, 777–786 (2022).

C. Qian†, K. Miao†, L. Lin, X. Chen, J. Du, L. Wei*, Nature Communications, 3648 (2021). †Equal Contributions

L. Lin, K. Miao, C. Qian, L. Wei*, Analyst, 146, 4135-4145 (2021).

D. Lee, C. Qian, H. Wang, L. Lei, K. Miao, J. Du, D. M. Shcherbakova, V. V. Verkhusha, L.V. Wang, and L. Wei*, Journal of Chemical Physics, 154, 135102, (2021).

​

D. Lee, J. Du, R. Yu, Y. Su, J. Heath, and L. Wei*, Analytical Chemistry, 92, 13182, (2020).

J. Du†, Y. Su†, C. Qian, D. Yuan, K. Miao, D. Lee, A. Ng, R. Wijker, A. Ribas, R. Levine, J. Heath*, and L. Wei*, Nature Communications, 11, 4830, (2020). †Equal Contributions "Cancer’s hidden vulnerabilities"

K. Miao and L. Wei*, ACS Cent. Sci, 4, 478, (2020).

M. Wei†, L. Shi†, Y. Shen, Z. Zhao, A. Guzman, L. J. Kaufman, L. Wei* and Wei Min*, Proc. Natl. Acad. Sci. USA, 116, 6608, (2019). (†Equal Contributions *Co-corresponding)

H. Xiong†, L. Shi†, L. Wei, Y. Shen, R. Long, Z. Zhao and W. Min, Nat. Photonics, 13, 412 (2019). †Equal Contributions

Prior to Caltech:

20. Electronic Resonant Stimulated Raman Scattering Micro-Spectroscopy

J. Du†, X. Tao†, T. Begušić, & L. Wei, J. Phys. Chem. B, 127, 22, 4979–4988 (2023) (†Equal Contributions, *Co-corresponding)

J. Du†, Y. Su†, C. Qian, D. Yuan, K. Miao, D. Lee, A. Ng, R. Wijker, A. Ribas, R. Levine, J. Heath, and L. Wei, Nature Communications, 11, 4830, (2020). †Equal Contributions

"Cancer’s hidden vulnerabilities"

M. Wei†, L. Shi†, Y. Shen, Z. Zhao, A. Guzman, L. J. Kaufman, L. Wei* and Wei Min, Proc. Natl. Acad. Sci. USA, 116, 6608, (2019). (†Equal Contributions Co-corresponding)